STIMULATION OF C14-MELATONIN SYNTHESIS FROM C14-TRYPTOPHAN BY NORADRENALINE IN RAT PINEAL IN ORGAN CULTURE

Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture.

Previous work has shown that the activity of the melatonin-forming enzyme in the rat pineal gland is elevated in rats kept in continuous darkness as compared to those kept in continuous light. Information about environmental lighting reaches the pineal gland via nerves that liberate noradrenaline. Rat pineal glands in organ culture can form C(14)-melatonin from C(14)-tryptophan as follows: tryp...

Stimulation of(14C)serotonin synthesis from (14C)tryptophan by mescaline in rat pineal organ cultures.

substrate. Mescaline does not inhibit the deandnation of [14C] serotonin to 5-hydroxyindoleacetic acid and has no significant effect on the intracellular content of [14C] tryptophan or its conversion to [14G] protein. It is • 14 concluded that mescaline stimulates p_ne;¢l [ C] serotonin synthesis via a primary stimula£ory action on the enzymatic conversion of [14.C]tryptophan to 5-hydroxytrypto...

Melatonin formation in rat pineal gland organ culture: induction by an adrenergic beta 2-stimulating drug.

It is well known that the pineal gland hormone melatonin has a direct effect on pigment dispersion in amphibian melanocytes. This pineal hormone has also been reported to influence pituitary melanocyte-stimulating hormone (MSH) activity in the rat. Melatonin is formed from serotonin (5-hydroxytryptamine) in two metabolic steps: first, serotonin is enzymatically metabolized by N-acetyltransferas...

One-step preparation of C14-cyanide from barium carbonate-C14.

News and Notes Eighth Annual Calorimetry Conference; Symposium on the Role of Proteins in Ion Transport Across Membranes.. 710 Technical Papers One-Step Preparation of C14-Cyanide from Barium Carbonate-C14: J. K. Jeanes .719 Evaluation of Oral Temperature Readings: Francis L. Harmon.. 719 Use of the Thymus Gland in Chicks to Elucidate Interrelationships Between Pteroylglutamic Acid and Biologic...

Metabolism of Coprostanol-c14 and Cholestanol-4-c14 in Man.